![]() ![]() In this study, Dot-blot (DB) method was found to be an extremely promising tool as serologic screening technique, because of its high sensitivity, as well as a rapid diagnostic test, given the release of true negative results in less time (one day) compared to the double immunodiffusion assay in agarose gel (DI, seven days), considered the gold standard serological method and, therefore, of great diagnostic value, particularly for the disposal of clinical suspicion for the this mycosis. In addition, the technique used to immunodiagnostic of PCM has to combine sensitivity and specificity, so that the predictive value is high and reproducible. ![]() Given the above, an early and accurate diagnosis of this infectious disease is very important because it allows the establishment of appropriate antifungal therapy, reduction of unnecessary use of toxic drugs decreasing the use of empiric therapy, thereby minimizing the emergence of multidrug-resistant fungal strains. Paracoccidioidomycosis (PCM), a mycosis which clinical diagnosis can be confused with other infectious diseases like leishmaniasis and tuberculosis, presents significant rates of mortality, estimated between 2-23% in severe cases, reaching 30% when associated with AIDS, and considered to lead mortality among mycosis in Brazil, with an average of 111.5 deaths/year, according to the Mortality Information System of the Ministry of Health. Visit for more related articles at Journal of Infectious Diseases & Therapy Related article at Pubmed, Scholar Google This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. São Paulo, SP, 01246-902, Brazil Tel: +55113068 2900 Email: OctoAccepted: DecemPublished: December 28, 2015Ĭitation: Ayuka F, Barnett R (2015) Place Effects on Alcohol Consumption: A Literature Review. Laboratório de Imunodiagnóstico das MicosesĬentro de Imunologia, Instituto Adolfo LutzĪv. Dot-Blot Methodology for Rapid Diagnosis of Paracoccidioidomycosis Caused by Paracoccidioides brasiliensis Kamikawa CK 1, 2 and Vicentini AP 1, 2 *ġ Mycoses Immunodiagnostic Laboratory, Immunology Center, Adolfo Lutz Institute, São Paulo, BrazilĢ Postgraduate Program in Sciences, Disease Control Coordination, State Secretariat of Health of São Paulo, São Paulo, São Paulo, Brazil ![]()
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